Theme
Targeted protein degradation
Drugs that harness the cell's own disposal machinery to destroy disease-causing proteins rather than just inhibiting them.
Targeted protein degradation (molecular glues, PROTACs) recruits the ubiquitin-proteasome system to eliminate a target protein outright, reaching "undruggable" targets that conventional inhibitors can't. The modality is platform-like — one chemistry applied across many targets — which is why the leaders are valued on pipeline breadth, not a single asset.